Negative regulation of G0 to G1 transition

Across TCGA patient cohorts, RNA activity of the Negative regulation of G0 to G1 transition pathway is significantly associated with the RNA expression of multiple genes, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DAB2IP, PCDHB15, and PI4K2A, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of G0 to G1 transition activity versus DAB2IP in CCRCC (Pearson r = 0.29).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	DAB2IP →	+0.906	+0.715	<.001	.001	3	5
CCRCC	PCDHB15 →	+1.297	+0.766	<.001	<.001	3	3
CCRCC	PI4K2A →	-0.260	-0.541	.001	<.001	3	3
CCRCC	PRKCD →	-0.451	-0.547	.001	.006	3	3
CCRCC	PSIP1 →	+0.565	+0.898	<.001	<.001	3	3
PDAC	RHNO1 →	-0.233	-0.345	.003	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0070317 vs DAB2IP — CCRCC

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