G1 to G0 transition involved in cell differentiation

Across TCGA cell cohorts, RNA activity of the G1 to G0 transition involved in cell differentiation pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DENND11, DNAJC6, and LSM4, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, DENND11 grouped by G1 to G0 transition involved in cell differentiation-low versus -high activity in LUNG_SCLC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	DENND11 →	-1.166	-1.200	.005	<.001	3	4
LUNG_SCLC	DNAJC6 →	-1.897	-1.381	.003	<.001	3	3
LUNG_SCLC	LSM4 →	-0.492	-1.388	.007	<.001	3	3
LUNG_SCLC	AGPAT5 →	-0.785	-1.371	.001	<.001	3	3
LUNG_SCLC	ITGA5 →	+2.456	+0.940	.004	.009	3	3
LUNG_SCLC	CCDC112 →	-0.756	-1.073	.001	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

DENND11 by G1 to G0 transition involved in cell differentiation activity — LUNG_SCLC

Explore this box plot interactively →