Positive regulation of stress-activated protein kinase signaling cascade

Across TCGA cell cohorts, RNA activity of the Positive regulation of stress-activated protein kinase signaling cascade pathway is significantly associated with the RNA expression of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are HLA-B, FAM229B, and GLIPR1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, HLA-B grouped by Positive regulation of stress-activated protein kinase signaling cascade-low versus -high activity in LIVER.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	HLA-B →	-4.450	-1.573	.001	<.001	3	6
STOMACH	FAM229B →	-1.401	-1.404	.005	.001	3	6
CNS	GLIPR1 →	-2.144	-1.044	.004	<.001	3	6
CNS	UBTD1 →	-1.733	-1.349	<.001	<.001	3	6
BREAST	OSMR →	-1.822	-0.829	.001	<.001	3	5
LIVER	HLA-C →	-4.379	-1.793	.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

HLA-B by Positive regulation of stress-activated protein kinase signaling cascade activity — LIVER

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