Positive regulation of stress-activated protein kinase signaling cascade

Across TCGA cell cohorts, RNA activity of the Positive regulation of stress-activated protein kinase signaling cascade pathway is significantly associated with the shRNA dependency of multiple genes, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TEAD1, ZNF768, and ADH1B, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, TEAD1 grouped by Positive regulation of stress-activated protein kinase signaling cascade-low versus -high activity in BONE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	TEAD1 →	+0.338	+0.193	.002	.003	3	6
BONE	ZNF768 →	-0.307	-0.185	.001	<.001	3	5
PANCREAS	ADH1B →	+0.188	+0.082	<.001	.004	3	5
CNS	ROCK1 →	-0.200	-0.155	<.001	<.001	3	5
CNS	HMSD →	+0.192	+0.134	<.001	<.001	3	5
LIVER	HOXA3 →	+0.251	+0.138	.005	.007	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

TEAD1 by Positive regulation of stress-activated protein kinase signaling cascade activity — BONE

Explore this box plot interactively →