Negative regulation of stress-activated protein kinase signaling cascade

Across TCGA patient cohorts, RNA activity of the Negative regulation of stress-activated protein kinase signaling cascade pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are ADPRH, DOCK2, and ARHGAP30, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of stress-activated protein kinase signaling cascade activity versus ADPRH in OV (Pearson r = 0.01).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	ADPRH →	+0.459	+0.045	<.001	<.001	3	7
LSCC	DOCK2 →	+0.339	+0.043	<.001	<.001	3	7
LSCC	ARHGAP30 →	+0.346	+0.042	<.001	<.001	3	7
COAD	TIMP2 →	+0.601	+0.032	<.001	<.001	3	6
LSCC	SERPINB9 →	+0.369	+0.038	<.001	<.001	3	6
CCRCC	BTK →	+0.405	+0.032	<.001	.002	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0070303 vs ADPRH — OV

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