Negative regulation of stress-activated protein kinase signaling cascade

Across TCGA pan-cancer cohorts, RNA activity of the Negative regulation of stress-activated protein kinase signaling cascade pathway is associated with patient survival in 21 of 34 cancer lineages. Pathway activity is summarized from the expression of its 47 member genes.

The strongest signal is observed in skin cutaneous melanoma (SKCM), where higher Negative regulation of stress-activated protein kinase signaling cascade pathway activity is associated with better overall survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as SKCM and CESC, show the opposite pattern, with higher activity associated with better survival.

SKCM, UCEC, and ACC are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
SKCM	OS	Median	All	0.850	0.716	<.001	99	view →
UCEC	OS	Tertile	III,IV	0.689	0.880	.001	80	view →
ACC	OS	Quartile	All	0.375	0.853	<.001	70	view →
MESO	DFS	Tertile	IV	0.190	0.538	.011	52	view →
LGG	OS	Median	All	0.346	0.526	<.001	49	view →
KIRC	OS	Median	All	0.758	0.835	.002	40	view →
THCA	DFS	Tertile	III,IV	0.475	0.946	.004	32	view →
BLCA	DFS	Tertile	All	0.510	0.665	.001	31	view →
PAAD	OS	Quartile	All	0.335	0.595	.002	27	view →
DLBC	DFS	Median	IV	0.128	1.000	.017	14	view →
CESC	OS	Median	IV	0.841	0.360	.008	12	view →
LIHC	OS	Tertile	III,IV	0.729	0.312	.003	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 21 lineages.

GO:0070303–SKCM (OS)

Open the SKCM breakdown →