Negative regulation of stress-activated protein kinase signaling cascade

Across TCGA patient cohorts, RNA activity of the Negative regulation of stress-activated protein kinase signaling cascade pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PYROXD1, NACAD, and ADAMTS4, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of stress-activated protein kinase signaling cascade activity versus PYROXD1 in LSCC (Pearson r = 0.08).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	PYROXD1 →	+0.430	+0.611	<.001	<.001	3	4
GBM	NACAD →	-0.726	-0.736	<.001	.001	3	4
BRCA	ADAMTS4 →	-0.706	-0.716	.002	.003	3	4
LSCC	CCDC25 →	+0.330	+0.562	.004	.006	2	4
LSCC	RNU6-1079P →	+0.548	+0.510	.001	.004	3	3
LSCC	CPNE3 →	+0.505	+0.651	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0070303 vs PYROXD1 — LSCC

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