Negative regulation of stress-activated protein kinase signaling cascade

Across TCGA cell cohorts, RNA activity of the Negative regulation of stress-activated protein kinase signaling cascade pathway is significantly associated with the RNA expression of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CTDNEP1, EPRS1, and TIMM22, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CTDNEP1 grouped by Negative regulation of stress-activated protein kinase signaling cascade-low versus -high activity in PANCREAS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	CTDNEP1 →	-0.742	-0.144	<.001	.007	3	5
LIVER	EPRS1 →	-0.696	-0.294	.001	<.001	3	4
LIVER	TIMM22 →	-0.743	-0.245	<.001	.004	3	4
STOMACH	WNT10B →	-1.104	-0.194	.003	.007	3	4
STOMACH	B3GNT3 →	+4.433	+0.378	<.001	.001	3	4
LARGE_INTESTINE	NOC3L →	-0.610	-0.175	.009	.008	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CTDNEP1 by Negative regulation of stress-activated protein kinase signaling cascade activity — PANCREAS

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