Negative regulation of stress-activated protein kinase signaling cascade

Across TCGA cell cohorts, RNA activity of the Negative regulation of stress-activated protein kinase signaling cascade pathway is significantly associated with the RNA expression of multiple genes, with the KIDNEY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GSTP1, AGK, and CASP6, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of stress-activated protein kinase signaling cascade activity versus GSTP1 in KIDNEY (Pearson r = 0.76).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	GSTP1 →	+6.172	+0.303	.009	<.001	3	10
SKIN	AGK →	+0.915	+0.127	.001	.006	3	5
LUNG_SCLC	CASP6 →	+1.291	+0.179	.007	.002	3	5
LUNG_SCLC	DPYD →	-2.405	-0.160	<.001	<.001	3	5
OVARY	RENBP →	+1.465	+0.092	.001	.008	3	4
BLOOD_Lymphoma	MRGBP →	-0.604	-0.098	.008	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0070303 vs GSTP1 — KIDNEY

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