Regulation of stress-activated protein kinase signaling cascade

Across TCGA cell cohorts, RNA activity of the Regulation of stress-activated protein kinase signaling cascade pathway is significantly associated with the RNA expression of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are OAS3, NDST1, and MORN3, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, OAS3 grouped by Regulation of stress-activated protein kinase signaling cascade-low versus -high activity in LIVER.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	OAS3 →	-2.425	-0.404	<.001	.001	3	4
LUNG_NSCLC_LUSC	NDST1 →	-1.638	-1.774	<.001	<.001	3	4
LUNG_SCLC	MORN3 →	-1.241	-1.096	.002	.006	3	4
CNS	NEK11 →	-0.776	-0.722	<.001	<.001	3	4
CNS	YPEL5 →	-0.983	-0.831	.002	.002	3	4
BREAST	GADD45B →	-0.835	-0.747	.009	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

OAS3 by Regulation of stress-activated protein kinase signaling cascade activity — LIVER

Explore this box plot interactively →