Regulation of stress-activated protein kinase signaling cascade

Across TCGA cell cohorts, RNA activity of the Regulation of stress-activated protein kinase signaling cascade pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RNF125, MAPKAPK3, and ARL6IP5, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of stress-activated protein kinase signaling cascade activity versus RNF125 in BLOOD_Leukemia (Pearson r = 0.40).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	RNF125 →	+0.851	+0.106	.001	.003	3	5
BLOOD_Leukemia	MAPKAPK3 →	+1.084	+0.132	<.001	.003	3	4
BLOOD_Lymphoma	ARL6IP5 →	+1.096	+0.179	.002	.001	3	4
CNS	GNL3 →	+0.624	+0.179	.008	.006	3	4
LARGE_INTESTINE	POLR1B →	+0.394	+0.195	.005	.002	3	4
SKIN	CPT2 →	+0.688	+0.209	.005	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0070302 vs RNF125 — BLOOD_Leukemia

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