Sarcoplasmic reticulum calcium ion transport

Across TCGA patient cohorts, RNA activity of the Sarcoplasmic reticulum calcium ion transport pathway is significantly associated with the protein abundance of multiple proteins, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are WIPF1, MAPRE2, and TOP1, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Sarcoplasmic reticulum calcium ion transport activity versus WIPF1 in UCEC (Pearson r = 0.33).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	WIPF1 →	+0.441	+0.071	<.001	<.001	3	7
HNSC	MAPRE2 →	+0.333	+0.108	<.001	<.001	3	7
GBM	TOP1 →	-0.377	-0.064	<.001	<.001	3	6
UCEC	MSN →	+0.415	+0.071	<.001	<.001	3	6
UCEC	ADPRH →	+0.303	+0.043	<.001	<.001	3	6
UCEC	CLIC2 →	+0.592	+0.054	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0070296 vs WIPF1 — UCEC

Explore this scatter interactively →