Sarcoplasmic reticulum calcium ion transport

Across TCGA patient cohorts, RNA activity of the Sarcoplasmic reticulum calcium ion transport pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ASPA, ERO1A, and ADAMTS8, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Sarcoplasmic reticulum calcium ion transport activity versus ASPA in GBM (Pearson r = 0.37).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	ASPA →	+1.328	+0.767	<.001	.003	2	7
UCEC	ERO1A →	-0.632	-0.473	.002	.001	3	6
GBM	ADAMTS8 →	+0.605	+0.705	<.001	<.001	3	6
HNSC	MYL3 →	+0.879	+0.730	<.001	.003	3	5
LSCC	COL14A1 →	+0.820	+0.675	<.001	<.001	3	5
LSCC	PRKDC →	-0.468	-0.726	.002	.003	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0070296 vs ASPA — GBM

Explore this scatter interactively →