Sarcoplasmic reticulum calcium ion transport

Across TCGA cell cohorts, RNA activity of the Sarcoplasmic reticulum calcium ion transport pathway is significantly associated with the shRNA dependency of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MAN1A2, CADM1, and FAM32A, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, MAN1A2 grouped by Sarcoplasmic reticulum calcium ion transport-low versus -high activity in STOMACH.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	MAN1A2 →	+0.240	+1.022	.003	.003	3	4
LUNG_NSCLC_LUAD	CADM1 →	-0.149	-0.827	.002	.001	3	4
OVARY	FAM32A →	-0.353	-1.155	.003	<.001	3	3
OVARY	CACNA1C →	-0.381	-1.100	<.001	<.001	3	3
CNS	SLC38A3 →	+0.196	+0.863	.008	.008	3	3
OVARY	RBM7 →	-0.214	-0.856	.004	.007	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

MAN1A2 by Sarcoplasmic reticulum calcium ion transport activity — STOMACH

Explore this box plot interactively →