Sarcoplasmic reticulum calcium ion transport

Across TCGA cell cohorts, RNA activity of the Sarcoplasmic reticulum calcium ion transport pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are IRF9, SSX2IP, and PYURF, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Sarcoplasmic reticulum calcium ion transport activity versus IRF9 in LUNG_SCLC (Pearson r = 0.53).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	IRF9 →	+1.649	+0.358	<.001	<.001	3	5
PANCREAS	SSX2IP →	-1.118	-0.429	.001	.004	3	4
PANCREAS	PYURF →	-0.566	-0.411	.002	<.001	3	4
LARGE_INTESTINE	PHLDB2 →	+4.160	+0.371	<.001	.003	3	4
LARGE_INTESTINE	SAA1 →	+3.122	+0.441	<.001	<.001	3	4
PANCREAS	EDRF1 →	-0.593	-0.379	.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0070296 vs IRF9 — LUNG_SCLC

Explore this scatter interactively →