Renal absorption

Across TCGA cell cohorts, RNA activity of the Renal absorption pathway is significantly associated with the RNA expression of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are KRIT1, IL1F10, and PRDM10, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Renal absorption activity versus KRIT1 in PANCREAS (Pearson r = 0.54).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	KRIT1 →	+0.492	+0.835	.008	.008	3	4
OESOPHAGUS	IL1F10 →	-0.176	-1.211	.001	<.001	3	3
PANCREAS	PRDM10 →	+0.567	+0.850	.001	.007	3	3
PANCREAS	SMURF1 →	+0.684	+1.320	.002	.002	3	3
PANCREAS	SYNE2 →	+1.010	+1.076	.002	<.001	3	3
BONE	PHYH →	+1.365	+0.430	<.001	.001	2	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0070293 vs KRIT1 — PANCREAS

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