N-acylethanolamine metabolic process

Across TCGA patient cohorts, RNA activity of the N-acylethanolamine metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GDPD3, SUSD2, and GINS2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, N-acylethanolamine metabolic process activity versus GDPD3 in UCEC (Pearson r = 0.24).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	GDPD3 →	+0.977	+0.204	.001	.001	2	5
UCEC	SUSD2 →	+1.110	+0.321	<.001	.002	3	3
GBM	GINS2 →	-0.640	-0.110	<.001	.002	3	3
OV	SKA3 →	-0.609	-0.185	.001	.003	3	3
OV	RBM4B →	-0.252	-0.172	.005	.006	3	3
OV	GTSE1 →	-0.880	-0.186	.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0070291 vs GDPD3 — UCEC

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