Necroptotic process

Across TCGA patient cohorts, RNA activity of the Necroptotic process pathway is significantly associated with the protein abundance of multiple proteins, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are TRIM21, UBA7, and FAS, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Necroptotic process activity versus TRIM21 in HNSC (Pearson r = 0.46).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	TRIM21 →	+0.611	+0.061	<.001	<.001	3	8
HNSC	UBA7 →	+0.522	+0.069	<.001	<.001	3	8
GBM	FAS →	+0.859	+0.051	<.001	<.001	3	8
LSCC	GALM →	+0.410	+0.059	<.001	<.001	3	8
BRCA	RIPK3 →	+0.501	+0.031	<.001	.009	2	8
LSCC	CAMSAP3_S1074 →	-1.189	-0.045	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0070266 vs TRIM21 — HNSC

Explore this scatter interactively →