Necroptotic process

Across TCGA cell cohorts, RNA activity of the Necroptotic process pathway is significantly associated with the shRNA dependency of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DNM1L, USP28, and GALR1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, DNM1L grouped by Necroptotic process-low versus -high activity in CNS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	DNM1L →	-0.258	-0.773	.005	.005	3	6
SKIN	USP28 →	-0.329	-0.986	.004	.007	2	6
SKIN	GALR1 →	-0.080	-0.860	.006	<.001	3	5
SKIN	RELA →	-0.190	-0.783	<.001	.001	3	5
OVARY	INPP4B →	+0.254	+0.991	<.001	.002	3	4
URINARY_TRACT	RAB38 →	-0.257	-0.409	.002	.003	2	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

DNM1L by Necroptotic process activity — CNS

Explore this box plot interactively →