Actin-mediated cell contraction

Across TCGA cell cohorts, RNA activity of the Actin-mediated cell contraction pathway is significantly associated with the RNA expression of multiple genes, with the UPPER_AERODIGESTIVE_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are POLR1B, SRSF7, and MYBBP1A, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Actin-mediated cell contraction activity versus POLR1B in UPPER_AERODIGESTIVE_TRACT (Pearson r = -0.81).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	POLR1B →	-1.307	-0.515	<.001	.006	3	7
UPPER_AERODIGESTIVE_TRACT	SRSF7 →	-1.116	-0.558	.005	.001	3	6
OVARY	MYBBP1A →	-0.932	-0.226	.003	<.001	3	6
BLOOD_Leukemia	GPR63 →	-1.301	-0.245	.004	.007	3	6
LUNG_SCLC	KATNB1 →	-1.125	-0.247	.002	.001	3	6
PANCREAS	RNASEH1 →	-0.822	-0.285	.003	.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0070252 vs POLR1B — UPPER_AERODIGESTIVE_TRACT

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