Positive regulation of T cell apoptotic process

Across TCGA patient cohorts, RNA activity of the Positive regulation of T cell apoptotic process pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CD7, PATL2, and IDO1, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of T cell apoptotic process activity versus CD7 in BRCA (Pearson r = 0.22).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	CD7 →	+0.977	+0.963	<.001	<.001	3	8
HNSC	PATL2 →	+0.542	+0.713	.009	.001	3	8
HNSC	IDO1 →	+1.995	+0.899	<.001	<.001	3	7
HNSC	TOMM20P2 →	+0.950	+0.610	.002	.001	3	7
HNSC	TRG-AS1 →	+0.647	+0.665	<.001	.003	3	7
LUAD	CXCR2P1 →	+1.283	+0.937	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0070234 vs CD7 — BRCA

Explore this scatter interactively →