Negative regulation of lymphocyte apoptotic process

Across TCGA cell cohorts, RNA activity of the Negative regulation of lymphocyte apoptotic process pathway is significantly associated with the RNA expression of multiple genes, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CTNS, ETV6, and ADAMTSL5, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CTNS grouped by Negative regulation of lymphocyte apoptotic process-low versus -high activity in OESOPHAGUS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	CTNS →	-0.943	-0.165	.001	.009	3	5
LUNG_NSCLC_LUAD	ETV6 →	-0.718	-0.498	.007	.009	3	4
LIVER	ADAMTSL5 →	-1.089	-0.343	<.001	<.001	3	3
OVARY	RAI1 →	-0.615	-0.469	.007	.006	3	3
OESOPHAGUS	MAN1A1 →	+1.312	+0.223	.003	.002	3	3
LUNG_NSCLC_LUAD	MARF1 →	-0.752	-0.400	.002	.008	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CTNS by Negative regulation of lymphocyte apoptotic process activity — OESOPHAGUS

Explore this box plot interactively →