Negative regulation of lymphocyte apoptotic process

Across TCGA cell cohorts, RNA activity of the Negative regulation of lymphocyte apoptotic process pathway is significantly associated with the RNA expression of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FGD6, ARHGDIB, and WASF1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of lymphocyte apoptotic process activity versus FGD6 in LARGE_INTESTINE (Pearson r = -0.37).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	FGD6 →	-1.196	-0.132	.003	.001	3	4
BONE	ARHGDIB →	-4.092	-0.235	.002	.006	2	5
BONE	WASF1 →	-2.094	-0.274	.002	<.001	3	4
LUNG_NSCLC_LUAD	APLP1 →	+2.012	+0.161	.005	.001	3	4
LUNG_NSCLC_LUAD	MLF2 →	+0.627	+0.123	.002	.003	3	3
BLOOD_Lymphoma	BCL11A →	-3.411	-0.206	<.001	.005	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0070229 vs FGD6 — LARGE_INTESTINE

Explore this scatter interactively →