Protein trimerization

Across TCGA patient cohorts, RNA activity of the Protein trimerization pathway is significantly associated with the RNA expression of multiple genes, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CPEB4, TXNDC11, and APOL6, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Protein trimerization activity versus CPEB4 in LUAD (Pearson r = 0.15).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	CPEB4 →	+0.341	+0.140	.009	.008	2	6
HNSC	TXNDC11 →	+0.391	+0.106	.003	.002	3	5
OV	APOL6 →	+1.074	+0.298	.001	.007	3	5
HNSC	LCP2 →	+0.808	+0.153	.002	.003	3	5
LSCC	MEFV →	+0.611	+0.149	.001	.004	3	5
LSCC	ICAM3 →	+0.518	+0.171	.003	.006	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0070206 vs CPEB4 — LUAD

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