Protein trimerization

Across TCGA cell cohorts, RNA activity of the Protein trimerization pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TLR4, F2R, and FANCD2OS, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, TLR4 grouped by Protein trimerization-low versus -high activity in BLOOD_Leukemia.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	TLR4 →	-1.472	-0.548	.002	.006	3	4
BLOOD_Leukemia	F2R →	+2.010	+0.590	.001	.003	3	4
LUNG_NSCLC_LUSC	FANCD2OS →	+0.156	+0.228	.005	<.001	3	4
OVARY	SYTL3 →	-1.314	-0.417	.002	.008	3	3
LUNG_NSCLC_LUAD	RAB1A →	-0.478	-0.344	.002	.009	3	3
LUNG_NSCLC_LUAD	GOLM2 →	-0.497	-0.268	<.001	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

TLR4 by Protein trimerization activity — BLOOD_Leukemia

Explore this box plot interactively →