Regulation of establishment of protein localization to chromosome

Across TCGA cell cohorts, RNA activity of the Regulation of establishment of protein localization to chromosome pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Lymphoma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are USP7, RSL1D1, and RRN3, each associated with the pathway in up to 11 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of establishment of protein localization to chromosome activity versus USP7 in BLOOD_Lymphoma (Pearson r = 0.71).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	USP7 →	+1.177	+0.171	<.001	<.001	3	11
LUNG_SCLC	RSL1D1 →	+0.801	+0.146	<.001	.002	3	7
STOMACH	RRN3 →	+0.782	+0.185	.002	.003	3	7
PANCREAS	UQCRC2 →	+0.700	+0.193	.003	.007	3	6
BLOOD_Leukemia	ZNF174 →	+0.610	+0.140	<.001	<.001	3	6
LUNG_SCLC	GSPT1 →	+0.719	+0.140	<.001	.001	2	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0070202 vs USP7 — BLOOD_Lymphoma

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