"Protein localization to chromosome, telomeric region"

Across TCGA patient cohorts, RNA activity of the "Protein localization to chromosome, telomeric region" pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are UBTF_S484, HCFC1, and PDCD6IP, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, "Protein localization to chromosome, telomeric region" activity versus UBTF_S484 in LSCC (Pearson r = 0.27).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	UBTF_S484 →	+0.768	+0.040	<.001	<.001	3	6
HNSC	HCFC1 →	+0.204	+0.080	<.001	<.001	3	6
HNSC	PDCD6IP →	-0.259	-0.099	.002	<.001	3	6
OV	EPS8L2 →	-0.492	-0.029	.003	.005	2	7
LSCC	HMCES →	+0.471	+0.045	<.001	<.001	3	6
HNSC	POGZ →	+0.216	+0.064	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0070198 vs UBTF_S484 — LSCC

Explore this scatter interactively →