"Protein localization to chromosome, telomeric region"

Across TCGA pan-cancer cohorts, RNA activity of the "Protein localization to chromosome, telomeric region" pathway differs between tumor and matched normal tissue in 11 of the 18 cancer types tested.

The strongest signal is observed in thyroid carcinoma (THCA), where pathway activity is lower in tumor tissue than in matched normal tissue. In most cancer types, this pathway shows higher activity in tumors, although a few cancer types, such as THCA and KIRC, show the opposite pattern, with lower activity in tumor tissue.

THCA, HNSC, and LIHC show the most reproducible tumor–normal differences in pathway activity.

Tumor vs normal pathway activity by lineage

Ranked by sampling consensus. Activity change represents the tumor-versus-normal difference in pathway activity on a log₂ scale. Positive values indicate higher pathway activity in tumor tissue. The reported p-values are derived from the corresponding differential activity tests.

Lineage	Gender	Stage	Activity change	p	Sampling consensus
THCA	Male	III,IV	−0.071	<.001	11	view →
HNSC	Male	IV	+0.050	<.001	10	view →
LIHC	All	III,IV	+0.028	<.001	9	view →
KIRC	All	III,IV	−0.015	<.001	8	view →
CHOL	All	All	+0.071	<.001	5	view →
KICH	All	All	−0.028	.001	4	view →
COAD	Female	II,III,IV	+0.022	.006	4	view →
LUSC	All	All	+0.019	.001	4	view →
BRCA	Female	All	−0.018	.001	4	view →
LUAD	All	All	+0.022	.009	2	view →
PRAD	All	All	+0.017	.020	2	view →

Pink = more active in tumor, green = less active in tumor. Showing the 11 strongest of 11 lineages.

GO:0070198–THCA

Open the THCA breakdown →