"Protein localization to chromosome, telomeric region"

Across TCGA patient cohorts, RNA activity of the "Protein localization to chromosome, telomeric region" pathway is significantly associated with the RNA expression of multiple genes, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are IL1R2, PSMA6P2, and BZW1P2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, "Protein localization to chromosome, telomeric region" activity versus IL1R2 in COAD (Pearson r = -0.19).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	IL1R2 →	-0.998	-0.125	.001	.005	3	4
BRCA	PSMA6P2 →	-0.538	-0.103	.007	.001	3	4
COAD	BZW1P2 →	-0.570	-0.125	.007	.007	3	3
LUAD	BIVM →	+0.447	+0.084	.001	.001	3	3
BRCA	H3-5 →	-1.317	-0.126	<.001	.001	3	3
BRCA	ST13P3 →	-0.451	-0.116	.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0070198 vs IL1R2 — COAD

Explore this scatter interactively →