"Protein localization to chromosome, telomeric region"

Across TCGA cell cohorts, RNA activity of the "Protein localization to chromosome, telomeric region" pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TPP1, GBA, and TAF10, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, "Protein localization to chromosome, telomeric region" activity versus TPP1 in STOMACH (Pearson r = 0.67).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	TPP1 →	+1.528	+0.317	<.001	<.001	3	10
LIVER	GBA →	+1.240	+0.391	.001	<.001	2	7
URINARY_TRACT	TAF10 →	+1.021	+0.282	.001	<.001	3	6
BLOOD_Leukemia	GRN →	+1.391	+0.267	<.001	<.001	3	6
LUNG_NSCLC_LUSC	POLR2L →	+1.399	+0.303	<.001	<.001	3	6
SKIN	CHID1 →	+0.522	+0.215	<.001	.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0070198 vs TPP1 — STOMACH

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