"Protein localization to chromosome, telomeric region"

Across TCGA cell cohorts, RNA activity of the "Protein localization to chromosome, telomeric region" pathway is significantly associated with the protein abundance of multiple proteins, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are TPP1, CTSA, and PLBD2, each associated with the pathway in up to 19 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, "Protein localization to chromosome, telomeric region" activity versus TPP1 in STOMACH (Pearson r = 0.88).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	TPP1 →	+2.087	+0.352	<.001	<.001	3	19
SKIN	CTSA →	+1.523	+0.360	<.001	<.001	3	15
STOMACH	PLBD2 →	+1.318	+0.258	<.001	<.001	3	12
BONE	STIM1 →	+1.461	+0.328	<.001	.006	3	11
BONE	GLB1 →	+1.610	+0.348	.001	.002	3	11
BONE	HEXA →	+1.693	+0.449	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0070198 vs TPP1 — STOMACH

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