Synaptonemal complex organization

Across TCGA patient cohorts, RNA activity of the Synaptonemal complex organization pathway is significantly associated with the RNA expression of multiple genes, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TOP2A, CDCA5, and ABCA9, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Synaptonemal complex organization activity versus TOP2A in UCEC (Pearson r = 0.20).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	TOP2A →	+0.914	+0.463	.003	.002	3	4
UCEC	CDCA5 →	+0.757	+0.499	<.001	<.001	3	4
UCEC	ABCA9 →	-0.825	-0.661	.001	<.001	3	4
UCEC	WDHD1 →	+0.605	+0.652	.003	<.001	3	4
UCEC	LINC00517 →	-0.742	-0.485	.001	.001	3	4
UCEC	ASPM →	+0.750	+0.456	.004	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0070193 vs TOP2A — UCEC

Explore this scatter interactively →