Positive regulation of tooth mineralization

Across TCGA patient cohorts, RNA activity of the Positive regulation of tooth mineralization pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are ZEB2_S505, SYDE2_S60, and CFTR, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of tooth mineralization activity versus ZEB2_S505 in LSCC (Pearson r = -0.53).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	ZEB2_S505 →	-0.597	-0.513	.002	<.001	3	3
LSCC	SYDE2_S60 →	+0.641	+0.396	.001	<.001	3	3
BRCA	CFTR →	+1.931	+0.990	<.001	<.001	3	3
BRCA	DDX51_S103 →	+1.418	+1.303	<.001	<.001	3	3
OV	PPFIBP1_S40 →	-1.378	-0.314	<.001	<.001	3	3
PDAC	SLC4A2_S144 →	+0.822	+0.683	.002	.005	1	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0070172 vs ZEB2_S505 — LSCC

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