Positive regulation of biomineral tissue development

Across TCGA cell cohorts, RNA activity of the Positive regulation of biomineral tissue development pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ISG15, CAPRIN1, and CCNE1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of biomineral tissue development activity versus ISG15 in BREAST (Pearson r = 0.46).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	ISG15 →	+2.193	+1.139	.004	<.001	3	5
CNS	CAPRIN1 →	-0.378	-0.962	.006	.002	3	4
BLOOD_Leukemia	CCNE1 →	-0.973	-0.639	.001	.004	3	4
PANCREAS	MCM3 →	-0.987	-0.876	.006	.004	3	4
PANCREAS	CHAMP1 →	-0.773	-1.224	.009	.001	3	4
URINARY_TRACT	TOPBP1 →	-0.719	-1.620	.005	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0070169 vs ISG15 — BREAST

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