Negative regulation of biomineral tissue development

Across TCGA cell cohorts, RNA activity of the Negative regulation of biomineral tissue development pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are THAP3, PYGO1, and CZIB, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of biomineral tissue development activity versus THAP3 in BLOOD_Leukemia (Pearson r = -0.46).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	THAP3 →	-0.511	-0.521	.003	.006	3	5
BREAST	PYGO1 →	-1.124	-0.656	.001	.005	3	4
BLOOD_Lymphoma	CZIB →	-0.416	-0.556	.002	.003	3	4
LUNG_SCLC	STS →	+0.762	+0.408	.002	.001	3	4
BLOOD_Lymphoma	IGSF9B →	-1.554	-0.597	<.001	.001	3	3
BLOOD_Lymphoma	POMGNT1 →	-0.782	-0.500	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0070168 vs THAP3 — BLOOD_Leukemia

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