Regulation of biomineral tissue development

Across TCGA patient cohorts, RNA activity of the Regulation of biomineral tissue development pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are ITGA5_S127, ANTXR2, and COL6A3, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of biomineral tissue development activity versus ITGA5_S127 in BRCA (Pearson r = 0.43).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	ITGA5_S127 →	+0.834	+0.291	<.001	<.001	3	5
UCEC	ANTXR2 →	+0.498	+0.743	<.001	<.001	3	5
UCEC	COL6A3 →	+0.543	+0.729	<.001	<.001	3	4
OV	EZH2_T367 →	-1.470	-0.511	<.001	<.001	3	4
UCEC	ENTPD1 →	+0.440	+0.657	<.001	<.001	3	4
HNSC	MCM4 →	-0.577	-0.475	<.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0070167 vs ITGA5_S127 — BRCA

Explore this scatter interactively →