Regulation of biomineral tissue development

Across TCGA cell cohorts, RNA activity of the Regulation of biomineral tissue development pathway is significantly associated with the RNA expression of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TRIP11, DMAP1, and DCAF10, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, TRIP11 grouped by Regulation of biomineral tissue development-low versus -high activity in SOFT_TISSUE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	TRIP11 →	-0.600	-0.962	<.001	.003	3	4
BLOOD_Myeloma	DMAP1 →	-0.618	-1.315	<.001	<.001	3	3
STOMACH	DCAF10 →	-0.723	-1.006	.002	.005	3	3
OVARY	CYCS →	+0.908	+1.517	.002	<.001	3	3
SOFT_TISSUE	FAM78A →	-0.792	-1.307	<.001	<.001	3	3
SOFT_TISSUE	SULT4A1 →	-2.383	-1.474	.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

TRIP11 by Regulation of biomineral tissue development activity — SOFT_TISSUE

Explore this box plot interactively →