Regulation of biomineral tissue development

Across TCGA cell cohorts, RNA activity of the Regulation of biomineral tissue development pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MRPL10, IFI44, and INHBA, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of biomineral tissue development activity versus MRPL10 in LUNG_NSCLC_LUAD (Pearson r = -0.44).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	MRPL10 →	-0.501	-0.877	<.001	.001	3	4
BREAST	IFI44 →	+3.110	+0.910	<.001	.003	3	4
BREAST	INHBA →	+3.140	+1.234	.003	<.001	3	4
URINARY_TRACT	CREB3L1 →	+4.405	+1.831	.003	<.001	3	4
URINARY_TRACT	CHPF2 →	+0.661	+1.517	<.001	.004	3	4
BREAST	TRIM22 →	+1.544	+0.949	.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0070167 vs MRPL10 — LUNG_NSCLC_LUAD

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