Synaptic vesicle budding

Across TCGA cell cohorts, RNA activity of the Synaptic vesicle budding pathway is significantly associated with the RNA expression of multiple genes, with the UPPER_AERODIGESTIVE_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MCAM, TGFB1I1, and MYO10, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, MCAM grouped by Synaptic vesicle budding-low versus -high activity in UPPER_AERODIGESTIVE_TRACT.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	MCAM →	-2.481	-1.577	.009	<.001	3	6
BREAST	TGFB1I1 →	-1.858	-1.021	.004	<.001	3	5
OVARY	MYO10 →	-1.719	-1.114	.001	.002	3	5
SOFT_TISSUE	SCN1B →	-2.001	-1.265	.001	.003	3	5
STOMACH	CD302 →	-1.940	-1.592	.006	<.001	3	5
STOMACH	WASF1 →	-1.308	-0.966	.006	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

MCAM by Synaptic vesicle budding activity — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →