Positive regulation of mitochondrial translation

Across TCGA patient cohorts, RNA activity of the Positive regulation of mitochondrial translation pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are XPO5, DOCK5, and TNIP1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of mitochondrial translation activity versus XPO5 in LSCC (Pearson r = 0.37).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	XPO5 →	+0.388	+0.038	<.001	<.001	3	6
LSCC	DOCK5 →	-0.327	-0.056	<.001	<.001	3	5
GBM	TNIP1 →	-0.142	-0.035	.001	<.001	3	5
HNSC	MSH6 →	+0.360	+0.068	.004	.008	3	5
CCRCC	SH2D4A →	-0.214	-0.028	<.001	<.001	3	5
CCRCC	EVL_S246 →	+0.398	+0.039	.002	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0070131 vs XPO5 — LSCC

Explore this scatter interactively →