Positive regulation of mitochondrial translation

Across TCGA cell cohorts, RNA activity of the Positive regulation of mitochondrial translation pathway is significantly associated with the RNA expression of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SEMA4C, CCDC9, and TMEM39B, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SEMA4C grouped by Positive regulation of mitochondrial translation-low versus -high activity in CNS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	SEMA4C →	+0.825	+1.115	.003	.003	3	4
BLOOD_Myeloma	CCDC9 →	+1.512	+1.546	.001	.009	3	3
BLOOD_Myeloma	TMEM39B →	+1.067	+1.560	.005	.008	3	3
BLOOD_Myeloma	CCDC163 →	+2.296	+2.064	.008	.001	3	3
BLOOD_Myeloma	CLASP1 →	+1.307	+1.559	.009	.009	3	3
LUNG_SCLC	PHLDA1 →	+3.510	+1.717	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SEMA4C by Positive regulation of mitochondrial translation activity — CNS

Explore this box plot interactively →