Regulation of mitochondrial translation

Across TCGA patient cohorts, RNA activity of the Regulation of mitochondrial translation pathway is significantly associated with the protein abundance of multiple proteins, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RPRD2, TPR, and GRAMD4, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of mitochondrial translation activity versus RPRD2 in HNSC (Pearson r = 0.22).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	RPRD2 →	+0.190	+0.050	.001	.004	3	5
LSCC	TPR →	+0.151	+0.029	<.001	<.001	3	5
UCEC	GRAMD4 →	-0.431	-0.061	.003	.003	3	5
LSCC	CTTN_T401 →	-0.528	-0.036	.002	<.001	3	4
OV	CCDC12 →	+0.327	+0.034	.003	.001	3	4
GBM	RHBDF2_S387 →	-1.059	-0.070	<.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0070129 vs RPRD2 — HNSC

Explore this scatter interactively →