Regulation of mitochondrial translation

Across TCGA cell cohorts, RNA activity of the Regulation of mitochondrial translation pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LIMK1, LAMP1, and POLE4, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, LIMK1 grouped by Regulation of mitochondrial translation-low versus -high activity in BREAST.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	LIMK1 →	-0.860	-0.690	.005	.002	3	4
SOFT_TISSUE	LAMP1 →	-1.087	-1.349	.007	.003	3	4
CNS	POLE4 →	+1.134	+0.801	<.001	.006	3	3
UPPER_AERODIGESTIVE_TRACT	MYEOV →	+2.655	+1.424	.007	.009	2	4
BLOOD_Leukemia	NIPSNAP3A →	+0.738	+1.008	.001	.001	3	3
LUNG_SCLC	ZNF573 →	-0.906	-1.335	.002	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

LIMK1 by Regulation of mitochondrial translation activity — BREAST

Explore this box plot interactively →