Mitochondrial translational elongation

Across TCGA patient cohorts, RNA activity of the Mitochondrial translational elongation pathway is significantly associated with the RNA expression of multiple genes, with the UVM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GFM2, GFM1, and NMD3, each associated with the pathway in up to 33 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Mitochondrial translational elongation activity versus GFM2 in UVM (Pearson r = 0.63).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UVM	GFM2 →	+1.139	+0.051	<.001	<.001	3	33
ACC	GFM1 →	+1.231	+0.076	<.001	<.001	3	33
ACC	NMD3 →	+1.252	+0.083	<.001	<.001	3	33
UVM	RIOK2 →	+0.697	+0.037	<.001	<.001	3	33
UVM	ARMC1 →	+1.005	+0.035	<.001	<.001	3	32
ACC	FKTN →	+1.163	+0.085	<.001	<.001	3	32

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0070125 vs GFM2 — UVM

Explore this scatter interactively →