Mitochondrial translational elongation

Across TCGA patient cohorts, RNA activity of the Mitochondrial translational elongation pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are GFM1, GMPS, and PHC3, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Mitochondrial translational elongation activity versus GFM1 in LSCC (Pearson r = 0.44).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	GFM1 →	+0.349	+0.049	.002	<.001	3	7
LSCC	GMPS →	+0.369	+0.043	.001	.002	3	6
BRCA	PHC3 →	+0.278	+0.034	.003	.005	3	6
LSCC	NMD3 →	+0.297	+0.046	<.001	<.001	3	6
UCEC	TFB2M →	+0.383	+0.058	.004	.009	3	5
OV	ABCF3 →	+0.496	+0.056	<.001	<.001	2	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0070125 vs GFM1 — LSCC

Explore this scatter interactively →