Mitochondrial translational elongation

Across TCGA cell cohorts, RNA activity of the Mitochondrial translational elongation pathway is significantly associated with the shRNA dependency of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GFM1, PTCD3, and MRPL44, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, GFM1 grouped by Mitochondrial translational elongation-low versus -high activity in BREAST.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	GFM1 →	-0.360	-0.723	<.001	<.001	3	8
LUNG_NSCLC_LUAD	PTCD3 →	-0.460	-0.512	<.001	.005	3	5
LUNG_SCLC	MRPL44 →	-0.346	-0.500	.001	<.001	3	5
LUNG_SCLC	TUFM →	-0.575	-0.453	<.001	.003	3	4
KIDNEY	MRPL15 →	-0.268	-0.343	<.001	.007	3	4
LUNG_NSCLC_LUAD	MRPL24 →	-0.246	-0.229	.001	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GFM1 by Mitochondrial translational elongation activity — BREAST

Explore this box plot interactively →