Ciliary neurotrophic factor-mediated signaling pathway

Across TCGA patient cohorts, RNA activity of the Ciliary neurotrophic factor-mediated signaling pathway pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are BZW2, SELENBP1, and FOSL2, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Ciliary neurotrophic factor-mediated signaling pathway activity versus BZW2 in GBM (Pearson r = -0.28).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	BZW2 →	-0.395	-0.089	<.001	<.001	3	7
LUAD	SELENBP1 →	+0.542	+0.068	<.001	<.001	3	7
LUAD	FOSL2 →	-0.384	-0.060	<.001	.007	3	7
GBM	ARRB1 →	+0.334	+0.052	<.001	.001	3	6
LSCC	RIF1_S782 →	-0.636	-0.123	<.001	<.001	3	6
LSCC	RRM1 →	-0.455	-0.136	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0070120 vs BZW2 — GBM

Explore this scatter interactively →