Ciliary neurotrophic factor-mediated signaling pathway

Across TCGA pan-cancer cohorts, RNA activity of the Ciliary neurotrophic factor-mediated signaling pathway pathway is associated with patient survival in 23 of 34 cancer lineages. Pathway activity is summarized from the expression of its 5 member genes.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher Ciliary neurotrophic factor-mediated signaling pathway pathway activity is associated with better overall survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as KIRC and LUAD, show the opposite pattern, with higher activity associated with better survival.

KIRC, LUAD, and PAAD are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	OS	Tertile	All	0.718	0.537	<.001	103	view →
LUAD	OS	Quartile	II,III,IV	0.801	0.561	.001	75	view →
PAAD	OS	Tertile	All	0.551	0.282	<.001	57	view →
MESO	OS	Quartile	II,III,IV	0.514	0.300	.008	43	view →
KICH	DFS	Median	III,IV	1.000	0.468	.008	32	view →
DLBC	DFS	Median	III,IV	0.140	0.917	.010	17	view →
SARC	OS	Tertile	All	0.806	0.678	.014	14	view →
ESCA	DFS	Quartile	All	0.651	0.400	.006	12	view →
THCA	DFS	Tertile	All	0.656	0.923	.017	12	view →
OV	OS	Median	IV	0.621	0.856	.011	10	view →
LUSC	OS	Median	III,IV	0.777	0.537	.011	8	view →
TGCT	OS	Quartile	All	0.918	1.000	.041	6	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

GO:0070120–KIRC (OS)

Open the KIRC breakdown →