Ciliary neurotrophic factor-mediated signaling pathway

Across TCGA patient cohorts, RNA activity of the Ciliary neurotrophic factor-mediated signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SH2D3C, ARRB1, and SPRR1B, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Ciliary neurotrophic factor-mediated signaling pathway activity versus SH2D3C in BRCA (Pearson r = 0.25).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	SH2D3C →	+0.632	+0.570	.001	.005	3	6
BRCA	ARRB1 →	+0.777	+0.597	.001	.002	3	5
LUAD	SPRR1B →	-1.016	-0.278	.003	.008	3	4
OV	ADCY4 →	+0.562	+0.251	.002	.007	3	4
BRCA	FGD3 →	+1.523	+0.859	<.001	<.001	3	4
BRCA	RAPGEF3 →	+0.853	+0.761	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0070120 vs SH2D3C — BRCA

Explore this scatter interactively →