Ciliary neurotrophic factor-mediated signaling pathway

Across TCGA cell cohorts, RNA activity of the Ciliary neurotrophic factor-mediated signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are KDM4D, ZNF211, and MAMLD1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, KDM4D grouped by Ciliary neurotrophic factor-mediated signaling pathway-low versus -high activity in BREAST.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	KDM4D →	-0.434	-0.772	<.001	<.001	3	4
LUNG_SCLC	ZNF211 →	-0.807	-1.052	.002	.005	3	4
LUNG_SCLC	MAMLD1 →	+1.490	+1.259	.007	.004	3	4
LUNG_SCLC	RALGAPB →	-0.872	-1.691	<.001	<.001	3	4
LUNG_NSCLC_LUAD	CAPN12 →	+1.092	+0.438	.002	.008	3	4
STOMACH	C17orf97 →	-1.339	-1.060	.003	.004	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

KDM4D by Ciliary neurotrophic factor-mediated signaling pathway activity — BREAST

Explore this box plot interactively →